Ching-Yi Wu

Oral Biology

Affiliations

Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University

Faculty Appointments (in chronological order)

Feb 21 - Associate Professor, Institute of Oral Biology, National Yang Ming Chiao Tung University, Taiwan

Feb 19 – Jan 21 Associate Professor, Institute of Oral Biology, National Yang-Ming University, Taiwan

Aug 11 - Jan 19 Assistant Professor, Institute of Oral Biology, National Yang-Ming University, Taiwan

Feb 11 – Jul 11 Assistant Professor, Department of Dentistry, National Yang-Ming University, Taiwan

Dentistry-related certificates

May 25 – Family Dentistry

Dec 22 – Oral Pathology

Sep 01 – Dentist

Education (in chronological order)

Sep 03 – Aug 09 Ph.D, Oral Biology, University of Washington, USA

Sep 95 – Aug 01 DDS, National Yang-Ming University, Taiwan

Fellowship Appointment (in chronological order)

Jun 25 – Fellowship, Advance HE, UK

Nov 09 – Jan 11 Postdoctoral Research, Institute of Oral Biology, National Yang-Ming University, Taiwan

Administrative Appointments (in chronological order)

Oct 23 – Jul 25 Associate Chairperson, Department of Dentistry, National Yang Ming Chiao Tung University, Taiwan

Nov 23 – Oct 26 Secretary-General, Taiwan Academy of Oral Pathology

Nov 23 – Oct 25 Supervisor, Taiwan Association of Dental Sciences

Tel: (+886)-2-28267247

Fax: (+886)-2-2826-4053

E-mail: cywu3@nycu.edu.tw

Fields of Specialty:

Oral pathology, salivary gland physiology, oral microbiology

Research Description:

As an oral pathologist and educator, my work focuses on the intersection of oral health, systemic disease, and behavioral science. I am interested in how oral conditions interact with broader health outcomes in vulnerable populations, such as elderly people with systemic disorders. I integrate clinical dentistry, microbiology, public health, and psychology through interdisciplinary collaboration to better understand and address complex oral-systemic health challenges.

In a recent study, I examined how factors such as tooth loss and periodontal status are associated with different stages of the Alzheimer’s disease continuum—from subjective cognitive decline to dementia. I also collaborated with periodontists and conducted systematic reviews and meta-analyses to evaluate the treatment efficacy of non-surgical periodontal therapy with or without systemic antibiotics in diabetic patients. We also used the same method to assess the periodontal status of individuals with Sjögren’s syndrome. These projects aim to inform evidence-based clinical decision-making in patients with systemic comorbidities.

My research further extends into oral microbiology and disease risk. For instance, I involved in an investigation identifying the link between untreated caries and cariogenic bacteria among Taiwanese adolescents, which has implications for pathogen-based prevention strategies. In virology, I demonstrated that epigallocatechin-3-gallate (EGCG), in combination with acyclovir, can effectively inhibit HSV-1 infection in oral epithelial cells. Earlier in my career, I also explored the antimicrobial properties of functional foods. I published findings on the inhibitory effects of a commercial yogurt drink on Streptococcus mutans, providing insight into dietary approaches to caries prevention.

My research is grounded in methodological rigor and guided by a commitment to holistic, patient-centered care. I strive to contribute meaningful evidence to dentistry and public health, and my work has been published in high-impact journals such as Journal of Dentistry, Japanese Dental Science Review, and BMC Psychology.

Research Projects/Grants:

Aug 23 – Jul 24 How hypoxia affects expression of noncoding RNA and cell functions in infected pulpal fibroblasts (NSTC 112-2314-B-A49-019-)

Key Publications:(*: corresponding author)

Wu, S. Y., C. Y. Wu, Y. S. Lin, C. S. Lin, W. J. Lee, S. J. He, G. H. Lin, H. Y. Huang and J. L. Fuh (2025, Sep). Oral health variables associated with factors across the Alzheimer's disease continuum: from subjective cognitive decline to dementia. Journal of Dentistry, 160: 105862. (SCIE, 7/158, DENTISTRY, ORAL SURGERY & MEDICINE).
Wang, M.C., Wu, C.Y., Chen, W.H., Liu, C.Y., Ho, Y.C. (2024, Dec). Exploring the behavioural determinants of compliance in resilient high-caries-risk patients who improved caries severity. BMC Psychology. (Accepted). (SSCI, 52/219, PSYCHOLOGY, MULTIDISCIPLINARY).
Lin, P.Y., Mai, H.Y., Wu, C.Y., Lin, H.C., Chi, L.Y. (2024, Oct). Association between untreated caries and cariogenic bacteria in adolescents in Taiwan. Journal of Dental Sciences, 19(4):2027-2034. (SCIE, 17/157, DENTISTRY, ORAL SURGERY & MEDICINE).
Wu, S.Y., Wu, C.Y., Lin, L.Y., Chen, Y.H., Huang, H.Y., Lia, Y.L., Lee, S.Y. (2023, Dec). Systemic antibiotics adjuvants to scaling and root planing in type 2 diabetic and periodontitis individuals: Systematic review with network meta-analysis. Japanese Dental Science Review, 59: 167-178. (SCIE, 4/157, DENTISTRY, ORAL SURGERY & MEDICINE).
Wu, C.Y., Yu, Z.Y., Chen, Y.C., Hung, S.L. (2021, Dec). Effects of epigallocatechin-3-gallate and acyclovir on herpes simplex virus type 1 infection in oral epithelial cells. Journal of the Formosan Medical Association, 120(12):2136-2143. (SCIE, 71/329, MEDICINE, GENERAL & INTERNAL).
Wu, S.Y., Wu, C.Y., Chen, M.H., Huang, H.Y., Chen, Y.H., Tsao, Y.P., Lai, Y.L., Lee, S.Y. (2021, Oct). Periodontal conditions in patients with Sjögren’s syndrome: A meta-analysis. Journal of Dental Sciences, 16(4):1222-1232. (SCIE, 17/157, DENTISTRY, ORAL SURGERY & MEDICINE).
Wu, C.Y., He, S.J., Mar, K., Hsu, C.Y., Hung, S.L. (2019, Jun). Inhibition of Streptococcus mutans by a commercial yogurt drink. Journal of Dental Sciences, 14(2):198-205. (SCIE, 17/157, DENTISTRY, ORAL SURGERY & MEDICINE).